Post by ldubhawksfan on Mar 24, 2017 17:01:51 GMT -5
:::lurker:::
I'm so sorry for your loss. Our recent loss was trisomy 18. So while I don't have any valuable experience with trisomy 4, I'm here if you want to talk. The genetic results were a hard thing to learn about. ((Hugs))
TTC #1 starting July 2013, RE last 2014 First Angel baby lost July 11, 2014 IUI #1 with injections successful: EDD 11/24/15 Rainbow baby DD born 11/14/15 TTC#2 October 2016 Second Angel baby lost Jan 5, 2017
Post by bootsorhearts on Mar 24, 2017 17:07:41 GMT -5
I'm sorry for your loss. I'm glad you got an answer of sorts even though it raises more questions.
I do know most of the cell free DNA testing that can be done 10-13 weeks only covers T21, T13 and T18. But there are also a lot of different brands now and they use different testing methods so it's possible one of them can test for T4, if you were to get pregnant again and wanted to rule it out.
I would guess its like most trisomies, maternal age can make all of them more likely but they are all still pretty rare and random.
Would you be able to sit down with your doctor and ask some questions?
Huge hugs to you, sorry you are dealing with all this.
I'm so sorry. I know how hard this stuff is. Unfortunately I don't have any insight to share but wanted to suggest that you could also ask on CAL. I know it's not as active these days but I do know some of the ladies there have experienced losses due to trisomy (not sure if anyone had trisomy 4 specifically) so they may have more insight or knowledge. ((Hugs))
I'm sorry for your loss and the results, it's hard to get that information. I would take your OB up on the offer to schedule a meeting with a genetic counselor. They will be able to provide you with the most information on the topic as well as answer any questions about recurrence etc. We met with one before doing NIPT testing and it was very helpful. Additionally, as part of a RPL panel they run genetic karyotyping on you and your husband to see if there any chromosomal issues that can lead to loss. This testing can be expensive though if insurance won't pay. BCBS paid for mine with having had two consecutive losses at the time, it was billed at around $3k (total for both of us).
Post by luciddreamer on Mar 25, 2017 11:04:06 GMT -5
I agree that seeing a genetic counselor would be helpful for you. My 2nd miscarriage was a trisomy 8, so i don't have any specific answers for you. When I had talked to my OB, he thought it was a fluke.
I'm glad that you got some answers about your loss, I know it's hard. ((Hugs))
I'm so sorry for your loss. My second and third losses were confirmed genetic: Triploidy and T16. I don't have experience with T4, but after our third loss our RE had us meet with their genetic counselor and it was immensely helpful to us, especially with regard to our decision making in how to proceed. I would definitely meet with a genetic counselor if I were you. I'm in the camp of Gimme All The Info.
I'm sorry for your loss. I'm glad you got an answer of sorts even though it raises more questions.
I do know most of the cell free DNA testing that can be done 10-13 weeks only covers T21, T13 and T18. But there are also a lot of different brands now and they use different testing methods so it's possible one of them can test for T4, if you were to get pregnant again and wanted to rule it out.
I would guess its like most trisomies, maternal age can make all of them more likely but they are all still pretty rare and random.
Would you be able to sit down with your doctor and ask some questions?
Huge hugs to you, sorry you are dealing with all this.
Most first tri losses are due to a trisomy and they occur due to an error in division of the chromosomes during formation of the sperm or egg. I think it can happen equally to any chromosome. The reason we test for 13, 18 and 21 is that those are the only ones that can make it through pregnancy (other than the sex chromosomes). Some people seem to have more bad eggs or sperm that others and of course it is age dependent as well. Also some people seem to be less likely to have a chromosomally bad embryo implant. There is no way to prevent trisomies other than IVF with PGD. I hope this was helpful info and not annoying.
Post by therealbug on Mar 26, 2017 15:20:30 GMT -5
Hey @mattsgirl2004, I'm so sorry for the loss of your sweet boy but I'm glad you were able to get some answers. I agree with the above posters about seeing a genetic counselor and having genetic testing done on you and your husband. With 6 losses, it could be well worth it to find out if one of you have a balanced translocation, especially if you have not had genetic testing done on any of your prior losses.
With my loss, the reason was Trisomy 9. I went for counseling with the MFM at my hospital and both DH and I had a karotype done to confirm that neither of us are carrying an extra chromosome (or partial). Once that was confirmed, the MFM felt as if it was something that would likely not happen again.
Our plan was to TTC and see what happened. If it happened again, then we were going to discuss other possibilities including ivf with embryo testing.
Post by holdingouthope on Mar 27, 2017 11:13:19 GMT -5
I have no insight, but I do have lots of (((hugs))) and love to offer. I think a discussion with the genetic counselor might be worth the trouble, especially if it helps you gain any insight. Thinking of you, sweet friend!
I'm lurking and rarely post but thought I could help out with this given I am a cytogeneticist....
Trisomy 4 is a very rare trisomy that has a very low recurrence risk (with any trisomy your baseline risk is typically maternal age, with your risk increasing negligibly until 40, and then starts to increase quickly). The only way to test for recurrence right now in any future pregnancy would be an invasive test (CVS or amnio) as the current NIPT technologies cover chromosomes 13, 18, 21, X and Y, as well as some common microdeletion syndromes (with lower sensitivity).
What type of genetic testing are you inquiring about specifically? Chromosome abnormalities, a lot of them random, are found in ~ half of pregnancy losses. There would be no genetic testing needed for yourself or your partner, unless it was segmental trisomy, which would suggest a balanced translocation in one of you. That is very unlikely the case.
Definitely go talk to a counsellor, but your recurrence risk is likely low.
Any more questions feel free to message me, but maybe tag someone who has contact with me outside of TCF, like holdingouthope, or therealbug.
Me: 34 DH: 33 plus two doodle dogs: Higgins and Oliver Met September, 1998 Started dating (seriously) September 25, 2002 Married September 25, 2010 One loss on August 26, 2013 at 13 weeks (D&C) TTA forever (for now)
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