I posted on the IVF check-in already that this was going to happen but I just got the call from the RE's cell phone, which is never good news. My E2 dropped and my progesterone is rising and I only had a couple of follies on each ovary (5 or 6 total) so we're officially out this month. He didn't even give us the option; we're just converting to an IUI and triggering tonight. The dominant follie is at least on my good side and not the surgically reconstructed side, so that is good news I guess but we still don't have much of a chance with MFI.
Anyhow, if anyone has any DOR experience, please chime in with thoughts about next steps. It'll probably be March when we cycle again. My protocol for this cycle is in my sig. High FSH a dose but that was basically it.
Married 10 years. DX: AMA, DOR, endo, one tube, +NK, homozygous MTHFR C677T, and abnormal endometrial function test. MFI with high DNA fragmentation and pericentric inversion on chromosome 9.
Post by lindseyp2012 on Jan 17, 2015 11:17:17 GMT -5
So sorry! Last minute treatment changes are no good! At least you can still do something and aren't totally benched. I know its still not ideal. Hang in there. Good luck with the IUI!
5 years TTC 2 c/p's 2 failed IUIs/1 cancelled IVF 1 failed IVF 1 failed FET BFP 12/1/15. We said goodbye to Tiny 1/4/16 Fresh cycle #3 2/16 8R/7M/5F BFP 5/12/16 We said goodbye to flutter on 5/27 and poprock on 5/28 BFP 8/30/16 We said goodbye to Samuel 10/3 (Trisomy 16) Moving on to Donor Embryos BFP 12/20/16 We said goodbye to Turtle 12/30
Honestly, the IUI is just to make me and RE feel like we're doing something rather than nothing. We have less than a 5% chance of it working but figured what the hell, I've already grown some eggs, might as well.
firstbbq I think you're doing an EPP protocol. How long will you be on the estrogen patches for? Did you start with BCP or not? I'll be watching you to keep an eye on how things go!
@buttmonkey did you do the long Lupron or flare? How many days? That sounds like an awesome response, either way. Basically I'm just curious about whether or not EPP or MDLF is more aggressive. Will wait to see what Dr. Jeopardy has to say but he said on our call that we're going to go in an entirely different direction so I'm glad he isn't just going to jack up my FSH dosage.
Married 10 years. DX: AMA, DOR, endo, one tube, +NK, homozygous MTHFR C677T, and abnormal endometrial function test. MFI with high DNA fragmentation and pericentric inversion on chromosome 9.
A stupid question: if you're not suppressing in the first part of your cycle (pre-O) do you have to abstain during your fertile days? I mean, if they're going to start you on other stuff post-O just to make sure you don't develop a follicle before your cycle, don't they want to make sure you're not KU?
Married 10 years. DX: AMA, DOR, endo, one tube, +NK, homozygous MTHFR C677T, and abnormal endometrial function test. MFI with high DNA fragmentation and pericentric inversion on chromosome 9.
Me: 28-DX: Unexplained Infertility-HSG-All Clear-B/W- All normal levels DH: 29-SA-All Normal Married May 23rd, 2009- NTNP May 2013-TTC August 2013 First RE appt. Oct. 2014 Feb. 2015-Lap removed 8 cm mucinous cystadenoma in appendix IUI #1- 3/31- BFN IUI #2- 4/29- BFP
TTC #1: March 2014 Dx: MFI Medicated IUI #1: March 2015-BFP Baby Girl born 11/5/2015! TTC #2: August 2016 Medicated IUI #1: Feb 2017-BFN Medicated IUI #2: March 2017-BFP Baby Boy expected Dec. 1
lemonliz I'll be on an estrogen patch for about 7 days (from 7 days post O this cycle until I get my period). I guess this is based on the fact that I have very regular, 27/ 28-day cycles. So far my calendar shows 10 days of stims, but of course that will adjust if needed. No BCP for me. It wasn't even discussed with this new RE. My former RE (the one I've most recently been cycling with, whom I got another opinion from about IVF) was going to do BC, but she said it was only because they had to do batch cycling due to the small size of the clinic. I didn't like that the decision on my protocol was being made because of clinic constraints. In addition to the driving distance, this is why we decided not to cycle there.
See, that's the rub! We're batch cycled at my clinic, too, which is the reason why I was on BCP for almost 5 weeks. I get that batching is necessary when you're at a "boutique" clinic with one RE and two nurses, but at the same time I wonder how they're going to navigate those waters again.
Married 10 years. DX: AMA, DOR, endo, one tube, +NK, homozygous MTHFR C677T, and abnormal endometrial function test. MFI with high DNA fragmentation and pericentric inversion on chromosome 9.
Me (30) MH (32) Dx: MFI (low all the things) M. 10/11. TTC Since 01/14 IUI#1-3(Letrozole + Trigger) = BFN Second Opinion. Changed RE's. IVF 09/15 Long Lupron 12R/9M/8F, Transferred 1=BFN. 4 frosties. FET #1 12/15 Transferred 1 (3 still on ice)
Post by BunnyBerry on Jan 17, 2015 12:55:38 GMT -5
Nooooo Liz! I am so sorry!
Since you have never given up hope for our "hopeless" IUIs, I'm totally rooting for you on this converted cycle! It's 5x better chances than TI, right? That's a 500% increased chance of a BFP.
Any way that you could use BCPs to time a natural cycle right so you could start batching with the right amount of time on BCPs for the next try? I would be so frustrated if I wasn't being given the best chance of a response just to fit a schedule with the other patients.
I'm so sorry lemon. That's so disappointing. Hugs. I would talk to your RE about EPP instead of bcp (supposed to be better for poor responders). My understanding is that the flare approach is usually offered for those who are AMA in addition to being poor responders. It might be worth looking into. I'll keep my fx for you for your IUI.
Low Ovarian Reserve (low AMH), poor egg quality, abnormal EFT (glandular developmental arrest, endo). TTC with open ID donor sperm. Non-bio mommy to DD (born to DW 2013). IUIs 1-7 = BFN. IVF #1 Sept 2014: 8R, 5M, 3F, 5 day transfer of 1 morula = BFN. IVF#2 Jan/Feb 2015 13R, 11M, 9F, 5 day transfer of a 5AA blast, BFFN. FET#1 (DW as carrier) May 2015 5AA & 4AA = BFP! DD2 born February 2016
Me:24 DH:27 Married: 12/15/12 BFP May 2014 from IUI #2 after 8 months TTC B/G/G triplets born on 10/22/2015 at 25w5d After a total of 140 days in the NICU all three of my miracles came home!
MrsRC-33, MrRC-37. TTC#1 since 2/13. DX: T2 diet controlled diabetic, removed multiple fibroids blocking tubes, via robotic myomectomy, hysteroscopy and D&C on 5/15. CD3 b/w normal. HSG normal after surgery. On the bench April-June 2015. NTNP indefinitely. Loss mentioned.
I am so sorry to hear your IVF got cancelled. I also have a Dx of DOR and it sucks big time. My last IUI was cancelled due to early ovulation and I was very upset about the $3,000 we spent in meds that was for nothing. I blame MAYO for not bringing me in until CD 11 for U/S. I was also on Gonal F 300iu a day, which is the highest dose they will do for IUI. Mayo also told us that the only thing that may work for us is IVF with DE. We are going to two new RE's for different opinions this week. I can let you know what they tell me if you want. Obviously every person is different but just trying to help. Anyway, maybe they just need to figure out a different protocol for meds for you for it to work. Hang in there and GL with the IUI!
Post by ronniesgirl on Jan 17, 2015 14:48:21 GMT -5
I am so sorry you have been converted to IUI. I have been in exactly that spot and it sucks. It's hard to have any hope for the cycle. For me, MDLF was my absolute worst cycle. SG uses this for poor responders. Both of my second opinions said no way to MDLF and both recommended a version of EPP. Regarding BCPs, 2 of the 3 REs I've seen say BCPs do not suppress you. RMANJ believed they did whereas SG and SIRM said they did not. I pushed the RE at SIRM about this issue because his protocol (which is way different than anything the other REs recommended) included BCPs and lupron. It's been a while since we had this conversation, but his opinions was to the effect that DOR women have more male hormones and that BCPs help offset this. He also believes that lupron--when used briefly with BCPs--make the antral follicles more receptive to estrogen (estrogen priming protocol) and the estrogen makes the follicles more receptive to the stims. The truth is that you just never know what protocol is going to work for you, but the SIRM doc sold me. He convinced me that his protocol with BCPs and lupron and crazy high stims was a last ditch protocol and that I didn't have the luxury of trying anything but the most aggressive protocol out there. I would encourage you to get another opinion. I found both of my second opinions to be incredibly eye-opening. I can chat DOR all day, so let me know if you to chat any.
Post by ronniesgirl on Jan 17, 2015 14:53:02 GMT -5
Also wanted to add that I don't think your dosage is high. It's high for someone with a normal ovarian reserve, but not for DOR.The second opinion docs wanted 600 and 750. Not sure what the split will be between Gonal F and menopur, though. And the 750 may come down after a few days, but the idea was to flood the plains. One RE explained it's like flying: take-off requires a lot of fuel.
Post by ronniesgirl on Jan 17, 2015 14:58:18 GMT -5
My last post (for now anyhow), RMANJ wanted no BCPs and estrace during the luteal phase of the prior cycle before starting stims. I consider it to be the moderate approach inbetween SG and SIRM. He wanted 600 units of stims. I strongly considered it, but I've had one IVF BFN and 2 canceled IVFs, so I am definitely ready for the last ditch protocl (AKA the SIRM protocol).
Post by bluefairy5 on Jan 17, 2015 15:52:21 GMT -5
Ah, I had been wondering why you were on BCP for 5 weeks and change. I'm really glad to hear he's planning on going a totally different route next time, but I would be seriously surprised if the super long BCP stint didn't have something to do with it.
(((hugs))) again for the cancel. Even if there's a plan in place, and even if 5% on the IUI is still larger than 0% doing nothing, it still blows.
I'm so sorry! Did he give you follie measurements? Fx for a successful IUI! On my first cycle, we would have maybe converted to IUI but DH's sperm is not a candidate for IUI.
I'm having a better cycle this time on MDL and will be posting my update soon...this protocol is working better for me so far and almost doubling my response - I'm triggering tonight for Monday ER.
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