Clomid research

[lazyreader]

Someone is attempting to call me out about me stating that clomid should only be taken from an RE due to serious risks and a max of 6x per lifetime. (I was responding to a third person that said they're on round 6 of clomid)

I see the newbie blog says 6-12 cycles based on articles, but can you fine ladies help a mobile boarder out and show me said research?
Maybe we can add the links to the blog?

[brettanomyces]

I was just reading the wikipedia entry for Clomid that says the max 6x is a recommendation from the manufacturer.

en.wikipedia.org/wiki/Clomifene


That's all I've got. 

[daisy818]

Pretty sure the manufacturer, who makes $$$ off a product, is probably trustworthy when it comes to the cap they set. Although this is also balanced with preventing law suits, so they may be risk-averse and use the conservative end of the number. Really depends on the heartless (but rational) ratio of $$$ to be made vs. costs of settling lawsuits. But personally if they pick a number, my guess is that after that number the rate of lawsuits increases, so that would be my cut-off as well.

[brettanomyces]

Feb 25, 2015 1:58:03 GMT -5 ****** said:

Here is a link to the manufacturer information. Hope it works.
products.sanofi.com.au/aus_pi_clomid_20140926.pdf
Eta: it's under the precautions section. I would trust manufacturer prescribing info over a wiki source.

The wiki source is a study of the link between ovulation inducing medication and ovarian cancer. Presumably that study would have referred to the manufacturer's precautions? I don't know- I didn't investigate it that thoroughly and I'm not sure how medical reporting generally works. 

[meatandbandp]

The insert that comes with clomid says you should be closely monitored and that your chances of high order multiples are increased, as well as side effects of cysts. I think the main issue is that if you have tried clomid 6 times and it hasn't worked, its most likely not going to. The package insert also discusses that.

products.sanofi.com.au/aus_pi_clomid_20140926.pdf

[ghostmonkey]

Feb 25, 2015 10:15:28 GMT -5 brettanomyces said:

Feb 25, 2015 1:58:03 GMT -5 ****** said:

Here is a link to the manufacturer information. Hope it works.
products.sanofi.com.au/aus_pi_clomid_20140926.pdf
Eta: it's under the precautions section. I would trust manufacturer prescribing info over a wiki source.

The wiki source is a study of the link between ovulation inducing medication and ovarian cancer. Presumably that study would have referred to the manufacturer's precautions? I don't know- I didn't investigate it that thoroughly and I'm not sure how medical reporting generally works. 

It's a weak link at best, and really not a link.

The issue is with reaching the point of diminishing returns after taking it for so many cycles.

[mainewifey]

www.asrm.org/uploadedFiles/ASRM_Content/News_and_Publications/Practice_Guidelines/Committee_Opinions/use_of_clomiphene(1).pdf

Page 343 of this document from the American Society of Reproductive medicine says over 6 months is not generally recomended.